NCIt definition : The Ets family of transcription factors includes nuclear phosphoproteins that are
involved in cell proliferation, differentiation and oncogenic transformation. The
family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly
conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling
pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling
cascades. To direct signals to specific target genes, ETS proteins interact with other
transcription factors that determine the binding specificity of ETS proteins to RAS-response
elements in target genes.;