ETS Family Gene

Preferred Label : ETS Family Gene;

NCIt synonyms : ETS Family Proto-Oncogenes;

NCIt definition : The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, ETS proteins interact with other transcription factors that determine the binding specificity of ETS proteins to RAS-response elements in target genes.;

Détails

Origin ID

C18326;

UMLS CUI

C0812200;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ETS Family Protein [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_involved_in_molecular_abnormality
- ERG Gene Rearrangement [NCIt concept]
- ETS Family Gene Rearrangement [NCIt concept]
- ETS1 Gene Rearrangement [NCIt concept]
- ETV Gene Rearrangement [NCIt concept]
- ETV1 Gene Rearrangement [NCIt concept]
- ETV4 Gene Rearrangement [NCIt concept]
- ETV5 Gene Rearrangement [NCIt concept]
- ETV6 Gene Rearrangement [NCIt concept]
- FEV Gene Rearrangement [NCIt concept]
- FLI1 Gene Rearrangement [NCIt concept]
- SPI1 Gene Rearrangement [NCIt concept]
- t(11;22)(q24;q12) [NCIt concept]
- t(12;13)(p13.2;q12.2) [NCIt concept]
- t(12;15)(p13;q25) [NCIt concept]
- t(12;21)(p13.2;q22.1) [NCIt concept]
- t(16;21)(p11;q22) [NCIt concept]
- t(17;22)(q21;q12) [NCIt concept]
- t(21;22)(q22;q12) [NCIt concept]
- t(2;16)(q35;p11) [NCIt concept]
- t(3;12)(q23;p12.3) [NCIt concept]
- t(3;12)(q26.2;p13.2) [NCIt concept]
- t(7;12)(q36;p13) [NCIt concept]
- t(9;12)(p24;p13) [NCIt concept]
- t(9;12)(q34;p13) [NCIt concept]
gene_plays_role_in_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
genetic_biomarker_related_to
- ETS Family Fusion Gene [NCIt concept]
- ETS Family Fusion Protein [NCIt concept]
- ETS Family Gene Fusion Positive [NCIt concept]
- FET/ETS Family Fusion Gene [NCIt concept]
- TMPRSS2/ETS Family Fusion Gene [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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