Preferred Label : RevM10 Gene;
NCIt definition : RevM10 is a dominant-negative mutant of HIV-1 Rev gene, which encodes an RNA-binding
protein involved in nuclear trafficking of unspliced viral mRNAs. The fact that Rev
is essential for HIV-1 replication makes it an attractive target for antiviral approaches.
Based on the notion of intracellular immunization, in vitro studies that introduce
RevM10 gene into stem cells have demonstrated its ability to combat HIV-1 infection
in human hematopoietic cells.;
Alternative definition : NCI-GLOSS: An antiviral gene being studied for treatment of cancer in patients who
have HIV, the virus that causes AIDS.;
Codes from synonyms : CDR0000046715;
Origin ID : C18318;
UMLS CUI : C0796697;
Semantic type(s)
- concept_is_in_subset
