Pleural Mesothelioma In Situ

Preferred Label : Pleural Mesothelioma In Situ;

NCIt definition : A non-invasive mesothelial neoplasm that arises from the pleura. It is characterized by the proliferation of a single-layer of flat or cuboidal neoplastic mesothelial cells. Cytological atypia is absent or minimal. Mitoses are absent. BAP1 gene inactivation and/or CDKN2A gene homozygous deletion are present. Patients present with non-resolving pleural effusion. It may progress to invasive epithelioid mesothelioma.;

Neoplastic status : Uncertain Malignant Potential;

NCI Metathesaurus CUI : CL1771365;

Details

Origin ID

C183134;

UMLS CUI

C5668165;

Disease may have findings
- Mild Cytologic Atypia [NCIt concept]
Excludes anatomical site(s)
- Neck [NCIt concept]
Has associated anatomic sites
- Pleural Cavity [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Mitotic Activity [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Mesothelial Cell [NCIt concept]
disease_has_finding
- In Situ Lesion [NCIt concept]
- Non-Invasive Lesion [NCIt concept]
- Pleural Effusion [NCIt concept]
disease_has_normal_cell_origin
- Mesothelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Mesothelium [NCIt concept]
- Pleura [NCIt concept]
disease_has_primary_anatomic_site
- Pleural Cavity [NCIt concept]
disease_may_have_molecular_abnormality
- BAP1 Gene Mutation [NCIt concept]
- CDKN2A Gene Deletion [NCIt concept]

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