Preferred Label : Allogeneic Variable Delta 1 Gamma-delta T-lymphocytes GDX012;
NCIt synonyms : Gamma-delta T-cells GDX012; Allogeneic Vd1 gd T-lymphocytes GDX012; Allogeneic gd T-cells GDX012; Allogeneic Vd1 gd T-cells GDX012; Allogeneic Variable Delta 1 Gamma-delta T-cells GDX012;
NCIt definition : An off-the-shelf (OTS) preparation of allogeneic variable delta 1 (Vd1) gamma-delta
(gd) T-lymphocytes, with potential immunomodulating and antineoplastic activities.
Upon administration of the allogeneic Vd1 gd T-lymphocytes GDX012, these cells secrete
interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these
cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response
against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of
the immune system and do not require major histocompatibility complex (MHC)-mediated
antigen presentation to exert their cytotoxic effect. Vd1 gd T-cells, a subset of
gamma delta T-cells, recognize and are activated by cancer cells, and may therefore
have a stronger association with antitumor immune responses compared with other gamma
delta T-cell subtypes.;
Molecule name : GDX 012; GDX-012;
NCI Metathesaurus CUI : CL1770969;
Origin ID : C182633;
UMLS CUI : C5666897;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
