Preferred Label : Deoxycytidine Kinase Inhibitor TRE-515;
NCIt synonyms : dCK Inhibitor TRE-515;
NCIt related terms : TRE-515;
NCIt definition : An orally bioavailable inhibitor of deoxycytidine kinase (dCK), with potential antineoplastic
activity. Upon oral administration, dCK inhibitor TRE-515 targets, binds to and inhibits
the activity of dCK, an enzyme that catalyzes the rate-limiting reaction in the deoxyribonucleoside
salvage pathway in cancer cells. By inhibiting dCK, TRE-515 halts nucleotide synthesis
and prevents the metabolism of DNA precursors in tumor cells. This inhibits DNA replication
in and proliferation of cancer cells. dCK predominantly phosphorylates the deoxyribonucleoside
deoxycytidine (dC) and converts dC into deoxycytidine monophosphate. It is upregulated
in multiple tumor cell types in response to increased DNA synthesis needed for rapid
cancer cell proliferation.;
UNII : 8EK0RD3M21;
Molecule name : TRE 515; DI 87; TRE-515;
NCI Metathesaurus CUI : CL1771128;
Origin ID : C182445;
UMLS CUI : C5666885;
Semantic type(s)
- concept_is_in_subset
- has_target
