" /> Therapeutic Index - CISMeF





Preferred Label : Therapeutic Index;

NCIt synonyms : Therapeutic Window; Therapeutic Ratio;

NCIt definition : The difference between the concentration at which clinical benefit is seen and that at which toxicity occurs. It is expressed as the range between the median effective dose and the median toxic dose.The larger the therapeutic index the safer a drug is.;

Alternative definition : CDISC-GLOSS: The ratio of the dose that produces toxicity (denominator) to the dose that produces a clinically desired or effective response (numerator). NOTE: The therapeutic index is a measure of a drug's safety, because a larger value indicates a wide margin between doses that are effective and doses that are toxic. [After Finkel, R, Clark, M. A., Champe, P. C. & Cubeddu, L. X. (eds) Lippincott's Illustrated Reviews: Pharmacology 4th edn (Lippincott Williams & Wilkins, 2008).];

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31/05/2025


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