Preferred Label : Nirmatrelvir;
NCIt synonyms : SARS-CoV-2-3CL Protease Inhibitor PF-07321332; SARS-CoV-2 3CLpro Inhibitor PF-07321332;
NCIt definition : An orally bioavailable, peptidomimetic inhibitor of the severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) main protease (Mpro; 3C-like protease; 3CL protease; 3CLpro;
nsp5 protease), with potential antiviral activity against SARS-CoV-2 and other coronaviruses.
Upon oral administration, nirmatrelvir selectively targets, binds to, and inhibits
the activity of SARS-CoV-2 Mpro. This inhibits the proteolytic cleavage of viral polyproteins,
thereby inhibiting the formation of viral proteins including helicase, single-stranded-RNA-binding
protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease
and exoribonuclease. This prevents viral transcription and replication.;
UNII : 7R9A5P7H32;
CAS number : 2628280-40-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2628280-40-8
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G-SRS /a ;
Molecule name : PF 07321332; PF-07321332;
NCI Metathesaurus CUI : CL1770615;
Origin ID : C182119;
UMLS CUI : C5545149;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
