Preferred Label : Anti-HLA-G/CD3 Bispecific Antibody JNJ-78306358;
NCIt synonyms : T Cell Redirecting Bispecific Antibody JNJ-78306358;
NCIt definition : A bispecific antibody targeting the tumor-associated antigen (TAA) HLA-G histocompatibility
antigen, class I, G (human leukocyte antigen G; HLA-G) and the CD3 antigen found on
T-lymphocytes, with potential immune checkpoint inhibiting, immunomodulating and antineoplastic
activities. Upon administration, the anti-HLA-G/CD3 bispecific antibody JNJ-78306358
targets and binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and HLA-G found on
HLA-G-expressing tumor cells. This activates and redirects CTLs to HLA-G-expressing
tumor cells, which results in the CTL-mediated cell death of HLA-G-expressing tumor
cells. HLA-G, an immune checkpoint normally expressed at the maternal-fetal interface,
is expressed across multiple tumor types and plays a key role in cancer immune evasion.
It inhibits immune responses by binding to its inhibitory receptors on a variety of
immune cells, such as natural killer cells (NKs), T- and B-lymphocytes, and dendritic
cells (DCs).;
Molecule name : JNJ-78306358; JNJ 78306358;
NCI Metathesaurus CUI : CL1770680;
Origin ID : C182073;
UMLS CUI : C5666878;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
