NCIt definition : A human monoclonal antibody directed against human vascular endothelial growth factor
receptor 2 (VEGFR-2; VEGFR2), with potential anti-angiogenesis and antineoplastic
activities. Upon administration, pulocimab specifically binds to and inhibits VEGFR-2
on vascular endothelial cells, which may inhibit tumor angiogenesis and tumor cell
proliferation. VEGFR-2, a tyrosine-protein kinase that plays an essential role in
angiogenesis and the proliferation, survival, migration and differentiation of endothelial
cells, is overexpressed in certain tumor types.;
UNII : FDL8DA4XV4;
CAS number : 2428381-49-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2428381-49-9
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