Preferred Label : CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells;
NCIt synonyms : TGFbR-KO CAR-EGFR T Cells; TGFbeta Receptor II-Knockout EGFR CAR T Cells;
NCIt definition : A preparation of human T-lymphocytes genetically engineered to express an anti-epidermal
growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene and gene-edited
with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease
complex to disrupt expression of transforming growth factor-beta receptor II (TGFbRII),
with potential immunostimulatory and antineoplastic activities. Upon administration,
the CRISPR-Cas9 engineered TGFbRII-deleted anti-EGFR CAR T-cells target and bind to
the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells
may be lysed. EGFR, overexpressed by a variety of cancer cell types, plays a key role
in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. By
knocking out the expression of TGFbRII, the immunosuppressive cytokine TGF-beta is
unable to bind to the T-cells and prevent the activation of the T-cells. TGF-beta
contributes to the immunosuppressive nature of the tumor microenvironment (TME), and
plays a key role in promoting tumor initiation, metastasis, and suppressing anti-tumor
immunity.;
NCI Metathesaurus CUI : CL1664827;
Origin ID : C182002;
UMLS CUI : C5557411;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
