Preferred Label : Personalized Cancer Neoantigen Vaccine GAd-PEV;
NCIt synonyms : Prime Vaccine GAd-PEV; Great Ape Adenoviral Tumor-specific Neoantigen Priming Vaccine GAd-PEV; Adenoviral Tumor-specific Neoantigen Priming Vaccine GAd-PEV; Nous-PEV Priming Vaccine GAd-PEV; Personalized Vaccine GAd-PEV;
NCIt definition : A personalized neoantigen priming vaccine comprised of a great ape (gorilla) adenoviral
(GAd) vector encoding numerous patient-specific tumor neoantigens, which are identified
based on patient-specific tumor mutations obtained from the individual's tumor, with
potential immunostimulatory and antineoplastic activities. The neoantigens are the
same as the ones in the booster vaccine MVA-PEV. Upon administration of the priming
vaccine personalized cancer neoantigen vaccine GAd-PEV, the neoantigens are expressed
and presented to the immune system. This may induce CD8 and CD4 neoantigen-specific
T-cell responses against the patient's tumor cells expressing the neoantigens.;
Molecule name : GAd-PEV;
NCI Metathesaurus CUI : CL1664821;
Origin ID : C182000;
UMLS CUI : C5557409;
Semantic type(s)
- concept_is_in_subset
