Preferred Label : KRAS G12C Inhibitor BI 1823911;
NCIt definition : An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with
potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor BI
1823911 selectively targets, binds to and inhibits the activity of the KRAS G12C mutant,
thereby inhibiting KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS
family of oncogenes, serves an important role in cell signaling, division and differentiation.
Mutations of KRAS may induce constitutive signal transduction leading to tumor cell
growth, proliferation, invasion, and metastasis.;
Molecule name : BI-1823911; BI 1823911;
NCI Metathesaurus CUI : CL1664833;
Origin ID : C181997;
UMLS CUI : C5557406;
Semantic type(s)
- concept_is_in_subset
- has_target
