Preferred Label : Anti-KAAG1 Antibody-Drug Conjugate ADCT-901;
NCIt synonyms : Anti-KAAG1 ADC ADCT-901; Antibody-drug Conjugate ADCT-901; ADC ADCT-901;
NCIt definition : An antibody-drug conjugate (ADC) composed of 3A4, a humanized monoclonal antibody
directed against human kidney associated antigen 1 (KAAG1; RU2) and conjugated, through
a cathepsin-cleavable linker, to SG3199, a cytotoxic pyrrolobenzodiazepine (PBD) dimer,
with potential antineoplastic activity. Upon administration of anti-KAAG1 ADC ADCT-901,
the 3A4 moiety targets and binds to KAAG1, which is expressed on the surfaces of a
variety of cancer cell types. Upon endocytosis and enzymatic cleavage by cathepsin,
free PBD is released and forms highly cytotoxic DNA interstrand cross-links, thereby
blocking cell division and killing KAAG1-expressing cancer cells. KAAG1, overexpressed
by certain tumor cell types, plays a key role in tumor cell proliferation. Its expression
on healthy tissue is very restricted.;
Molecule name : ADCT-901; ADCT 901;
NCI Metathesaurus CUI : CL1664832;
Origin ID : C181996;
UMLS CUI : C5557405;
Semantic type(s)
- concept_is_in_subset
- has_target
