Preferred Label : Glecirasib;
NCIt synonyms : KRAS G12C Inhibitor JAB-21822;
NCIt definition : An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with
potential antineoplastic activity. Upon oral administration, glecirasib selectively
targets, binds to and inhibits the activity of the KRAS G12C mutant, thereby inhibiting
KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes,
serves an important role in cell signaling, division and differentiation. Mutations
of KRAS may induce constitutive signal transduction leading to tumor cell growth,
proliferation, invasion, and metastasis.;
UNII : UP75WH4QKM;
CAS number : 2657613-87-9;
Molecule name : JAB-21822; JAB 21822;
NCI Metathesaurus CUI : CL1664858;
Origin ID : C181904;
UMLS CUI : C5908096;
Semantic type(s)
- concept_is_in_subset
- has_target
