NCIt definition : Rheumatoid arthritis in which a patient's serum is positive for certain disease-related
antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated
protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is
more specific than RF which can be found in other pathologic conditions. The production
of these disease-associated antibodies may precede the development of clinical symptoms
by several years. Seropositive patients have a greater likelihood of developing extra-articular
complications and a more severe course of disease.;