Preferred Label : ACSS2 Inhibitor MTB-9655;
NCIt synonyms : Acetyl-CoA Synthetase 2 Inhibitor MTB-9655;
NCIt definition : An orally bioavailable small molecule inhibitor of the enzyme human acetyl coenzyme
A synthetase short chain family member 2 (ACSS2; acetyl CoA synthetase 2), with potential
antineoplastic activity. Upon oral administration, the ACSS2 inhibitor MTB-9655 selectively
targets, binds to and inhibits the activity of ACSS2. This prevents acetate metabolism
to acetyl-CoA which may lead to an inhibition of tumor cell proliferation. ACSS2,
an enzyme that converts acetate to acetyl-CoA, is upregulated in cancer cells in response
to low nutrient availability and hypoxia. Stressed cancer cells utilize acetate as
an alternative nutrient source for cell growth.;
Molecule name : MTB 9655; MTB-9655;
NCI Metathesaurus CUI : CL1664644;
Origin ID : C181770;
UMLS CUI : C5557255;
Semantic type(s)
- concept_is_in_subset
