Anti-CAIX CAR T Cells

Preferred Label : Anti-CAIX CAR T Cells;

NCIt synonyms : CAIX-targeted CAR-T Cells;

NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) carbonic anhydrase IX (CAIX; carbonic anhydrase 9; CA9; G250), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CAIX CAR T-cells target and bind to CAIX-expressing tumor cells, thereby inducing selective toxicity in CAIX-expressing tumor cells. CAIX is a member of the carbonic anhydrase family that is found in a majority of renal cell carcinomas while absent in most normal tissues.;

NCI Metathesaurus CUI : CL1664657;

Details

Origin ID

C181752;

UMLS CUI

C5557247;

Semantic type(s)
- Cell [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Carbonic Anhydrase 9 [NCIt concept]

Keyword's position in hierarchy(ies) :

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