Preferred Label : KRAS-G12C Inhibitor LY3537982;
NCIt synonyms : KRAS G12C Inhibitor LY3537982;
NCIt definition : An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with
potential antineoplastic activity. Upon oral administration, KRAS-G12C inhibitor LY3537982
selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling.
KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling,
division and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : LY 3537982; LY-3537982;
NCI Metathesaurus CUI : CL1664656;
Origin ID : C181751;
UMLS CUI : C5557246;
Semantic type(s)
- concept_is_in_subset
- has_target
