Preferred Label : Locally-acting Temozolomide Formulation SI-053;
NCIt synonyms : Temozolomide Formulation SI-053; TMZ Formulation SI-053; Temodex (TM); Temozolomide-based SI-053;
NCIt definition : A powder for gel formulation containing the cytotoxic alkylating agent temozolomide
(TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, immobilized
on the polymeric carrier dextran phosphate, with potential antineoplastic activity.
The TMZ formulation SI-053 forms a viscous gel upon reconstitution in water. Upon
local intraoperative administration of the gel into the cavity that is formed after
resection of the brain tumor, SI-053 allows for local and prolonged action of TMZ.
TMZ is converted at physiologic pH to the short-lived active compound 5-(3-methyl-(triazen-1-yl)-imidazole)-4-carboxamide
(monomethyltriazenoimidazole carboxamide; MTIC). The cytotoxicity of MTIC is due to
methylation of DNA, particularly at the O6 and N7 positions of guanine residues, resulting
in cell cycle arrest, inhibition of DNA replication and the induction of apoptosis.
The local administration of TMZ allows for the local destruction of the remaining
tumor cells immediately after the removal of the tumor and may prevent the recurrence
of tumor growth while having no severe systemic toxicity.;
Molecule name : SI-053; SI 053;
NCI Metathesaurus CUI : CL1664650;
Origin ID : C181749;
UMLS CUI : C5557244;
Semantic type(s)
- concept_is_in_subset
