Preferred Label : Vevoctadekin;
NCIt synonyms : Engineered IL-18 Variant ST-067; Engineered Interleukin-18 Variant ST-067;
NCIt definition : An engineered variant of the human cytokine interleukin-18 (IL-18; IL18), with potential
immunostimulating and antineoplastic activities. Upon administration of vevoctadekin,
the IL-18 variant binds to and activates the IL-18 receptor. This promotes T-cell
persistence and enhances the activity and maturation of natural killer (NK) cells,
which potentiates the immune response against tumor cells. The IL-18 variant is engineered
to preferably bind to the IL-18 receptor and not IL-18 binding protein (IL-18BP),
which acts as a decoy receptor of IL-18 and prevents the activation of IL-18 receptor
in the tumor microenvironment (TME).;
UNII : U778Z8U9D3;
CAS number : 2768756-51-8;
Molecule name : ST 067; ST-067;
NCI Metathesaurus CUI : CL1664805;
Origin ID : C181677;
UMLS CUI : C5557203;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
