Preferred Label : NY-ESO-1-expressing Artificial Adjuvant Vector Cells ASP0739;
NCIt synonyms : aAVCs ASP0739; aAVC ASP0739; NY-ESO-1-expressing aAVCls ASP0739;
NCIt definition : A preparation of artificial adjuvant vector cells (aAVCs) composed of modified human
cells engineered to express the tumor-associated antigen (TAA) New York esophageal
squamous cell carcinoma 1 (NY-ESO-1) and loaded with loaded with the cluster of differentiation
1d (CD1d) ligand alpha-galactosylceramide (alpha-GalCer; a-GalCer), with potential
immunostimulating and antineoplastic activities. Upon administration of the NY-ESO-1-expressing
aAVCs ASP0739, the presentation of α-GalCer by CD1d molecules on the cell surface
activates invariant NKT (iNKT) cells, thereby eliciting NY-ESO-1-specific NKT cell
responses against ASP0739. This in turn activates a natural killer (NK) cell response
against NY-ESO-1-expressing tumor cells. In turn, the NY-ESO-1 released from destroyed
ASP0739 is taken up by antigen-presenting cells (APCs), mainly by dendritic cells
(DCs), which in turn activates NY-ESO-1-specific cytotoxic T-lymphocytes (CTL) and
results in a CTL-mediated immune response against NY-ESO-1-expressing tumor cells,
thereby further destroying NY-ESO-1-expressing tumor cells. In addition, the activation
of antigen-specific memory T cells provides long-lasting anti-tumor effects against
the NY-ESO-1-expressing tumor cells.;
Molecule name : ASP-0739; ASP 0739;
NCI Metathesaurus CUI : CL1664725;
Origin ID : C181663;
UMLS CUI : C5557201;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
