Preferred Label : Representational Difference Analysis;
NCIt synonyms : RDA;
NCIt definition : This PCR technique enables researchers to compare the DNA of normal and afflicted
tissue to isolate the DNA regions gained or lost in disease carriers. The essence
of the technique is to compare two regions of DNA, one with a target sequence and
one without. The target sequence may be either DNA added to the genome, by a virus
or by genetic amplification, or DNA deleted from a normal chromosome, as in many cancers.
Pairing DNA fragments from healthy and diseased tissue allows researchers to quickly
identify missing or added DNA sequence and thereby pinpoint genetic alterations that
may be involved in disease. (from Cold Spring Harbor);
Origin ID : C18114;
UMLS CUI : C0597707;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- Semantic type(s)
