Preferred Label : Prinomastat;
NCIt synonyms : (3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide;
NCIt related terms : AG3340;
NCIt definition : A synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat
inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby
inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth
and invasion, and metastasis. As a lipophilic agent, prinomastat crosses the blood-brain
barrier. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called angiogenesis
inhibitors. Prinomastat is a matrix metalloproteinase inhibitor.;
UNII : 10T6626FRK;
InChIKey : YKPYIPVDTNNYCN-INIZCTEOSA-N;
CAS number : 192329-42-3;
Molecule name : AG3340;
Chemical formula : C18H21N3O5S2;
Codes from synonyms : 31682; CDR0000046016; CDR0000044862;
Origin ID : C1811;
UMLS CUI : C0919273;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
