N6-Adenosine-Methyltransferase Non-Catalytic Subunit

Preferred Label : N6-Adenosine-Methyltransferase Non-Catalytic Subunit;

NCIt synonyms : hMETTL14; METTL14; N6-Adenosine-Methyltransferase Subunit METTL14; Methyltransferase-Like Protein 14;

NCIt definition : N6-adenosine-methyltransferase non-catalytic subunit (456 aa, 52 kDa) is encoded by the human METTL14 gene. This protein plays a role in the promotion of mRNA methylation.;

NCIt note : N6-adenosine-methyltransferase non-catalytic subunit contains a degenerate active site that cannot bind donor or acceptor substrates. (UniProt); N6-adenosine-methyltransferase non-catalytic subunit forms a heterodimer with N6-adenosine-methyltransferase catalytic subunit (METTL3), which is known as the N6-methyltransferase complex. This complex methylates adenosine residues at the N6 position of the 5'-[AG]GAC-3' consensus site found in some mRNAs. Methylation of this site regulates mRNA stability, processing, translation efficiency and editing. (UniProt);

Details

Origin ID

C181098;

UMLS CUI

C3849295;

Automatic exact mappings (from CISMeF team)
- Methyltransferase 14, n6-adenosine-methyltransferase subunit [OMIM gene]
OMIM relation
- Methyltransferase 14, n6-adenosine-methyltransferase subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- METTL14 protein, human [MeSH Supplementary Concept]
- METTL14 protein, human [MeSH concept]
gene_encodes_gene_product
- METTL14 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_plays_role_in_biological_process
- Methylation [NCIt concept]
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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