Anti-GARP Monoclonal Antibody DS-1055a

Preferred Label : Anti-GARP Monoclonal Antibody DS-1055a;

NCIt synonyms : Anti-glycoprotein A Repetitions Predominant Monoclonal Antibody DS-1055a;

NCIt definition : An afucosylated human monoclonal antibody directed against the transforming growth factor beta (TGFbeta) activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing protein 32; LRRC32), with potential immunomodulating and antineoplastic activities. Upon administration, anti-GARP monoclonal antibody DS-1055a selectively targets and binds to GARP and depletes GARP-positive regulatory T-cells (Tregs). This leads to a reversal of immunosuppression mediated by GARP-positive Tregs and enhances the immune response to tumor cells. GARP, a transmembrane protein highly expressed on activated, immunosuppressive Tregs in the tumor microenvironment (TME), is essential for the expression of TGFbeta on the cell surface of activated Tregs; it plays an important role in regulation of the immune cell function and the immunosuppressive nature of Tregs.;

Molecule name : DS 1055a; DS-1055a;

NCI Metathesaurus CUI : CL1663701;

Details

Origin ID

C181077;

UMLS CUI

C5556833;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Leucine-Rich Repeat-Containing Protein 32 [NCIt concept]

Keyword's position in hierarchy(ies) :

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