Preferred Label : Sovilnesib;
NCIt synonyms : KIF18A Inhibitor AMG 650;
NCIt related terms : AMG-650;
NCIt definition : An orally bioavailable, small-molecule inhibitor of the human kinesin-like protein
KIF18A, with potential antineoplastic activity. Upon oral administration, sovilnesib
selectively inhibits the activity of KIF18A. This may result in multipolar cell division
and inhibit tumor cell proliferation. KIF18A, a mitotic kinesin-8 motor protein, plays
an important role in the regulation of chromosome positioning during cell division
and is overexpressed in certain cancers. Certain cancer cells with chromosomal instability
(CIN) features depend on KIF18A activity for bipolar spindle integrity and cell proliferation.;
UNII : OP393M4H32;
CAS number : 2410796-79-9;
Molecule name : AMG-650; AMG 650;
NCI Metathesaurus CUI : CL1663595;
Origin ID : C181039;
UMLS CUI : C5706856;
Semantic type(s)
- concept_is_in_subset
- has_target
