Preferred Label : Peptide-drug Conjugate OPD5;
NCIt synonyms : PDC OPD5; Peptide Drug Conjugate OPD5;
NCIt definition : A peptide-drug conjugate (PDC) composed of a peptide conjugated, via an aminopeptidase-targeting
linkage, to an as of yet undisclosed alkylating agent, with potential antineoplastic
activity. Upon administration, PDC OPD5 is hydrolyzed by peptidases to release the
alkylating agent, thereby allowing for specific accumulation of the agent in aminopeptidase-positive
tumor cells. This may result in the inhibition of DNA and/or RNA synthesis and the
induction of apoptosis, thereby inhibiting tumor cell proliferation. Peptidases are
overexpressed by certain cancer cells.;
Molecule name : OPD-5; OPD 5;
NCI Metathesaurus CUI : CL1663606;
Origin ID : C181017;
UMLS CUI : C5556782;
Semantic type(s)
- concept_is_in_subset
