Preferred Label : Imipenem-Cilastatin-Relebactam;
NCIt synonyms : Imipenem/Cilastatin Sodium/Relebactam;
NCIt definition : A parenteral antibiotic preparation containing imipenem, cilastatin sodium and relebactam,
with bactericidal activity. Imipenem, a broad spectrum beta-lactam carbapenem antibiotic,
binds to and inactivates penicillin-binding proteins (PBP) on the inner membrane of
the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan
chains critical for bacterial cell wall strength and rigidity. Cilastatin sodium,
a renal dehydropeptidase inhibitor, reduces the breakdown of imipenem by renal dehydropeptidase.
Relebactam, a beta-lactamase inhibitor, reduces the breakdown of imipenem by certain
serine beta-lactamases among gram-negative bacteria. Imipenem is active against a
wide range of gram-positive and gram-negative organisms, and the imipenem, cilastatin
sodium and relebactam combination may be used to treat infections caused by resistant
gram-negative bacteria.;
Drug name : Recarbrio;
NCI Metathesaurus CUI : CL1663614;
Origin ID : C181013;
UMLS CUI : C5196218;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
