Preferred Label : BRD9 Degrader FHD-609;
NCIt synonyms : BRD9 Protein Degrader FHD-609;
NCIt definition : A protein degrader of bromodomain-containing protein 9 (BRD9; sarcoma antigen NY-SAR-29;
rhabdomyosarcoma antigen MU-RMS-40.8), with potential antineoplastic activity. FHD-609
is comprised of an E3 ligase-binding moiety and a BRD9-binding moiety. Upon administration,
BRD9 degrader FHD-609 targets and binds to BRD9 with its BRD9-binding moiety. Upon
BRD9 binding, the E3 ligase-binding moiety binds to a receptor on the E3 ligase complex
which directs proteins for destruction, resulting in the degradation of BRD9. This
leads to an inhibition of the growth of tumor cells that rely on BRD9 for survival.
BRD9, a component of one form of the Brg/Brahma-Associated Factor (BAF) complex, is
needed for the survival of certain cancer cells due to mutations.;
Molecule name : FHD-609; FHD 609;
NCI Metathesaurus CUI : CL1663531;
Origin ID : C180972;
UMLS CUI : C5556760;
Semantic type(s)
- concept_is_in_subset
- has_target
