Preferred Label : EGFR/EGFRvIII Inhibitor CM93;
NCIt definition : An orally bioavailable, blood-brain-barrier (BBB) penetrable, third-generation, covalent
inhibitor of epidermal growth factor receptor (EGFR) and various EGFR mutations, including
the EGFR variant III (EGFRvIII) mutant form, with potential antineoplastic activity.
Upon oral administration, EGFR/EGFRvIII inhibitor CM93 specifically targets, irreversibly
binds to and inhibits EGFR and specific EGFR mutations, which prevents EGFR/EGFR mutant-mediated
signaling and leads to cell death in EGFR/EGFR mutant-expressing tumor cells. EGFR,
a receptor tyrosine kinase (RTK) that is mutated in many tumor cell types, plays a
key role in tumor cell proliferation and survival.;
Molecule name : CM-93; CM 93;
NCI Metathesaurus CUI : CL1663647;
Origin ID : C180909;
UMLS CUI : C5556710;
Semantic type(s)
- concept_is_in_subset
- has_target
