Preferred Label : Anti-EGFR Antibody-drug Conjugate ABBV-637;
NCIt synonyms : Anti-EGFR ADC ABBV-637; Anti-EGFR/Bcl-XL Inhibitor ADC ABBV-637;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a monoclonal antibody directed against
the epidermal growth factor receptor (EGFR) conjugated to an inhibitor of Bcl-extra
large (Bcl-XL), with potential antineoplastic activity. Upon administration of anti-EGFR
ADC ABBV-637, the monoclonal antibody moiety targets and binds to EGFR on tumor cell
surfaces. Following receptor internalization, the Bcl-XL inhibitor is released, which
targets, binds to and inhibits the activity of Bcl-XL. This restores apoptotic processes
in EGFR-expressing tumor cells and inhibits the proliferation of EGFR-expressing tumor
cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a
key role in tumor cell proliferation and tumor vascularization.;
Molecule name : ABBV-637; ABBV 637;
NCI Metathesaurus CUI : CL1663656;
Origin ID : C180902;
UMLS CUI : C5557621;
Semantic type(s)
- concept_is_in_subset
- has_target
