Preferred Label : Anti-CD226 Agonist Antibody LY3435151;
NCIt synonyms : Anti-DNAM-1 Agonist Antibody LY3435151; Anti-CD226 Agonistic Antibody LY3435151;
NCIt definition : An agonistic antibody targeting the human cell surface glycoprotein CD226 (DNAX accessory
molecule-1; DNAM-1), with potential immunostimulatory and antineoplastic activities.
Upon administration, anti-CD226 agonist antibody LY3435151 targets and binds to CD226
on a variety of immune cell types, including T-cells, natural killer (NK) cells, B-cells
and monocytes. This induces CD226-dependent signaling pathways, which may trigger
the activation of antigen-presenting cells (APCs) and activate T-cells and NK cells.
This may result in an enhanced cytotoxic T-lymphocyte (CTL)-mediated and NK cell-mediated
immune response against tumor cells. CD226, a cell surface glycoprotein that functions
as an adhesion molecule, is expressed on various immune cells and plays an important
role in the co-activation of T-cells and NK cells upon interaction with its ligands
CD155 and CD112.;
Molecule name : LY 3435151; LY-3435151;
NCI Metathesaurus CUI : CL1663658;
Origin ID : C180889;
UMLS CUI : C5556693;
Semantic type(s)
- concept_is_in_subset
- has_target
