Preferred Label : Topical Keratinocyte Growth Factor Hair Serum;
NCIt synonyms : Keratinocyte Growth Factor Hair Serum; KGF-HS; Topical KGF-HS; Topical KGF Hair Serum;
NCIt definition : A topical formulation of keratinocyte growth factor (KGF; fibroblast growth factor
7; FGF-7) with potential use for the prevention and treatment of chemotherapy-induced
alopecia. Upon topical administration, topical KGF hair serum acts similarly to endogenous
KGF and binds to the KGF receptor. This results in stimulation of proliferation and
differentiation of epithelial cells and upregulation of cytoprotective mechanisms,
which may prevent and treat chemotherapy-induced alopecia. The KGF receptor is expressed
on epithelial cells in the skin, including hair follicles and sebaceous glands, and
other tissues; the KGF pathway plays an important role in hair follicle growth and
differentiation.;
NCI Metathesaurus CUI : CL1663451;
Origin ID : C180856;
UMLS CUI : C5556667;
Semantic type(s)
- concept_is_in_subset
