Preferred Label : Allogeneic Cytokine-induced Memory-like NK Cells WU-NK-101;
NCIt synonyms : Allogeneic CIML NKs WU-NK-101;
NCIt definition : A population of off-the-shelf (OTS) donor-derived cytokine-induced, memory-like, cytotoxic
natural killer (NK) cells (CIML NKs) containing NK cell-activating surface receptors,
with potential immunomodulating and antineoplastic activities. The allogeneic NK cells
are pre-activated ex vivo using the human-derived cytokines interleukin (IL)-12, IL-15,
and IL-18, which induces the differentiation of the NK cells into CIML NK cells, which
contain more NK cell-activating surface receptors. The pretreated NK cells exhibit
enhanced activation and increased production of the cytokine interferon-gamma (IFN-g),
and may exert enhanced cytotoxicity against tumor cells, including enhanced antibody-dependent
cellular cytotoxicity (ADCC). Upon administration, the CIML NKs WU-NK-101 may induce
an anti-tumor immune response and kill tumor cells.;
Molecule name : WU-NK 101;
NCI Metathesaurus CUI : CL1663464;
Origin ID : C180829;
UMLS CUI : C5556653;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
