Preferred Label : Lutetium Lu 177-FAP-2286;
NCIt synonyms : 177Lu Labeled DOTA-conjugated Peptide FAP-2286; Lutetium-177-FAP-2286; 177Lu-FAP-2286;
NCIt definition : A radioconjugate composed of FAP-2286, a fibroblast activation protein (FAP)-targeted
peptide, attached to the chelating agent 1,4,7,10-tetraazacyclododecane-N,N',N,N'-tetraacetic
acid (DOTA), and radiolabeled with the beta-emitting radioisotope lutetium Lu 177,
with potential antineoplastic activity. Upon administration of lutetium Lu 177-FAP-2286,
the FAP-2286 moiety targets and binds to FAP-expressing cancer-associated fibroblasts
(CAFs) and FAP-expressing tumor cells. Upon binding and internalization, this radioconjugate
specifically delivers a cytotoxic dose of beta radiation to CAFs and tumor cells.
FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment
(TME) and certain tumor cells.;
NCI Metathesaurus CUI : CL1663486;
Origin ID : C180806;
UMLS CUI : C5556639;
Semantic type(s)
- concept_is_in_subset
- has_target
