NCIt definition : A humanized bispecific gamma delta T-cell engager (TCE) antibody directed against
both CD1d and Vdelta2, with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CD1d gamma delta T-cell engaging bispecific antibody LAVA-051
binds to both CD1d-expressing tumor cells and Vgamma9Vdelta2 T-cells. This activates
and redirects the Vgamma9Vdelta2 T-cells to CD1d-expressing tumor cells, and the Vgamma9Vdelta2
T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells.
The Vgamma9Vdelta2 T-cells also activate the immune system to exert a cytotoxic T-lymphocyte
(CTL) response against tumor cells. In addition, this activates invariant natural
killer T-cells (iNKTs). The iNKTs secrete large amounts of various cytokines, which
may activate the immune system against tumor cells. Additionally, iNKTs directly target
and lyse tumor cells. CD1d, an antigen-presenting glycoprotein, plays an important
role in the presentation of glycolipid antigens to iNKTs; it is also expressed by
various hematologic malignancies.;