Preferred Label : Esomeprazole Topical Cream;
NCIt synonyms : Dermaprazole;
NCIt definition : A topical cream formulation containing the proton pump inhibitor (PPI) esomeprazole,
with potential antioxidant, anti-inflammatory and antifibrotic activities. Upon topical
administration, esomeprazole inhibits the enzyme dimethylarginine dimethylaminohydrolase
(DDAH), which increases the levels of the nitric oxide synthase (NOS) inhibitor asymmetric
dimethylarginine (ADMA). In addition, esomeprazole increases the expression of the
antioxidant enzyme heme oxygenase-1 (HO-1). Together, these actions reduce oxidative
stress which may protect cells from reactive oxygen species (ROS), cellular damage,
inflammation and fibrosis.;
NCI Metathesaurus CUI : CL1663393;
Origin ID : C180671;
UMLS CUI : C5556545;
Semantic type(s)
- concept_is_in_subset
