Preferred Label : IKZF2 Protein Degrader DKY709;
NCIt synonyms : Helios Degrader DKY709; Protein Degradation Agent DKY709; IKZF2 Protein DKY709;
NCIt definition : A low molecular weight (MW) degrader of the protein IKZF2 (Helios), with potential
immunomodulating and antineoplastic activities. Upon administration, IKZF2 protein
degrader DKY709 modulates the E3 (ubiquitin) ligase and allows for the interaction
between the E3 ubiquitin ligase substrate receptor and its target protein IKZF2, thereby
targeting IKZF2 for ubiquitination. This induces proteasome-mediated degradation of
IKZF2, which is a transcriptional repressor in T-cells, and modulates the activity
of the immune system. This may induce the activation of T-lymphocytes and the induction
of T-cell-mediated anti-tumor immune responses. IKZF2, a zinc finger transcription
factor expressed on the majority of regulatory T-cells (Tregs) and a member of the
Ikaros transcription factor family, plays a key role in cancer immune signal transduction
and immunosuppression.;
Molecule name : DKY-709; DKY 709;
NCI Metathesaurus CUI : CL1662985;
Origin ID : C180613;
UMLS CUI : C5556501;
Semantic type(s)
- concept_is_in_subset
- has_target
