" /> Gemtuzumab Ozogamicin - CISMeF





Preferred Label : Gemtuzumab Ozogamicin;

NCIt synonyms : hP67.6-Calicheamicin; Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody;

NCIt related terms : gemtuzumab; Mylotarg;

NCIt definition : A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI04);

Alternative definition : NCI-GLOSS: A monoclonal antibody combined with a toxic substance that is used to treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Mylotarg is a type of antibody-drug conjugate.;

UNII : 8GZG754X6M;

CAS number : 220578-59-6;

Drug name : Mylotarg;

Molecule name : CDP-771; WAY-CMA-676; CMA-676;

Chemical formula : C73H96IN6O25S3;

NSC code : 720568;

Codes from synonyms : CDR0000508999; CDR0000509002; CDR0000045569; 244;

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06/05/2025


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