Preferred Label : Anti-EGFR Antibody-drug Conjugate MRG003;
NCIt synonyms : Anti-EGFR/MMAE Antibody-drug Conjugate MRG003; Anti-EGFR ADC MRG003;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a human immunoglobulin G1 (IgG1) monoclonal
antibody directed against the epidermal growth factor receptor (EGFR) conjugated to
monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting
agent, with potential antineoplastic activity. Upon administration of anti-EGFR ADC
MRG003, the monoclonal antibody moiety binds to EGFR on tumor cell surfaces. Following
receptor internalization, the MMAE moiety is released and binds to tubulin and inhibits
its polymerization, which results in G2/M phase arrest and apoptosis. This inhibits
the proliferation of EGFR-expressing tumor cells. EGFR, overexpressed by a variety
of cancers, plays a key role in tumor cell proliferation and survival.;
Molecule name : MRG-003; MRG 003;
NCI Metathesaurus CUI : CL1662947;
Origin ID : C180585;
UMLS CUI : C5556477;
Semantic type(s)
- concept_is_in_subset
- has_target
