Preferred Label : Becotatug Vedotin;
NCIt synonyms : Anti-EGFR/MMAE Antibody-drug Conjugate MRG003; Anti-EGFR ADC MRG003; Anti-EGFR Antibody-drug Conjugate MRG003;
NCIt definition : An antibody-drug conjugate (ADC) consisting of becotatug, a humanized immunoglobulin
G1 (IgG1) monoclonal antibody directed against the epidermal growth factor receptor
(EGFR) conjugated to monomethyl auristatin E (MMAE), an auristatin derivative and
potent microtubule disrupting agent, with potential antineoplastic activity. Upon
administration of becotatug vedotin, the monoclonal antibody moiety binds to EGFR
on tumor cell surfaces. Following receptor internalization, the MMAE moiety is released
and binds to tubulin and inhibits its polymerization, which results in G2/M phase
arrest and apoptosis. This inhibits the proliferation of EGFR-expressing tumor cells.
EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation
and survival.;
UNII : VHA6L8H5FM;
CAS number : 2770851-80-2;
Molecule name : MRG-003; MRG 003;
NCI Metathesaurus CUI : CL1662947;
Origin ID : C180585;
UMLS CUI : C5556477;
Semantic type(s)
- concept_is_in_subset
- has_target
