PEG-modified/Site-mutated IL-2 SHR-1916

Preferred Label : PEG-modified/Site-mutated IL-2 SHR-1916;

NCIt synonyms : IL-2 Derivative SHR-1916; PEG-modified/site-mutated Interleukin-2 SHR-1916;

NCIt definition : A polyethylene glycol (PEG)-modified and site-mutated form of the cytokine interleukin-2 (IL-2), with potential immunopotentiating and antineoplastic activities. Upon administration, PEG-modified/site-mutated IL-2 SHR-1916 activates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This induces the selective proliferation of CD8 T-cells and natural killer (NK) cells, enhances tumor cell killing and decreases tumor cell proliferation. Pegylation of IL-2 protects the cytokine from degradation.;

Molecule name : SHR 1916; SHR-1916;

NCI Metathesaurus CUI : CL1662951;

Details

Origin ID

C180581;

UMLS CUI

C5556473;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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