Beta Tubulin Polymerization Inhibitor CCI-001

Preferred Label : Beta Tubulin Polymerization Inhibitor CCI-001;

NCIt synonyms : Colchicine Derivative CCI-001;

NCIt definition : A colchicine derivative and beta tubulin polymerization inhibitor, with potential antineoplastic activity. Upon administration, beta tubulin polymerization inhibitor CCI-001 targets, binds to and inhibits beta-III tubulin (TUBB3), and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells. TUBB3, overexpressed in many cancers, is associated with poor outcomes and a reduced response to taxane-based microtubule-targeting antineoplastic agents.;

Molecule name : CCI 001; CCI-001;

NCI Metathesaurus CUI : CL1663047;

Details

Origin ID

C180528;

UMLS CUI

C5556444;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin Beta-3 Chain [NCIt concept]

Keyword's position in hierarchy(ies) :

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