Preferred Label : Tremtelectogene Empogeditemcel;
NCIt synonyms : Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSCs VOR33; eHSCs VOR33; Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSPCs VOR33; Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive Hematopoietic Stem and Progenitor
Cells VOR33; Trem-cel;
NCIt definition : A preparation of allogeneic, human leukocyte antigen (HLA) matched, cluster of differentiation
34 (CD34)-positive human hematopoietic stem and progenitor cells (HSPCs) that are
ex-vivo gene-edited with the clustered regularly interspaced short palindromic repeats
(CRISPR)-Cas9 nuclease complex to remove the cluster of differentiation 33 (CD33)
antigen, that can potentially be used to improve hematopoietic recovery after hematopoietic
cell transplantation (HCT) and CD33-targeting chemotherapy. Upon administration, tremtelectogene
empogeditemcel increases and restores the number of HSPCs, which may prevent or decrease
infection and other complications of HCT and chemotherapy-induced neutropenia (CIN).
The removal of CD33 protects VOR33 from the cytotoxic effects of CD33-targeted agents
administered after HCT.;
UNII : CT5FM8JN3S;
Molecule name : VOR 33; VOR-33;
NCI Metathesaurus CUI : CL1663066;
Origin ID : C180524;
UMLS CUI : C5783437;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
