NCIt definition : A depot formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel,
with antineoplastic activity. Upon intratumoral administration, docetaxel depot formulation
NZ-DTX forms a solid depot allowing the controlled release of docetaxel. Docetaxel
binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin
and inhibiting microtubule disassembly, which results in cell-cycle arrest at the
G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as
vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory
response.;
Semantic type(s)