Preferred Label : Keynatinib;
NCIt definition : A third-generation, orally available inhibitor of the epidermal growth factor receptor
(EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration,
keynatinib binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation,
inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated
signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor
tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor
cell proliferation and tumor vascularization.;
Molecule name : TL-007; TL 007;
NCI Metathesaurus CUI : CL1663082;
Origin ID : C180507;
UMLS CUI : C5556426;
Semantic type(s)
- concept_is_in_subset
- has_target
