NCIt definition : The sodium salt form of cimderlirsen, an antisense oligonucleotide targeting the growth
hormone receptor (GHR; somatotropin receptor) mRNA, with potential somatotropin-inhibiting
activity. Upon subcutaneous administration, cimderlirsen hybridizes with GHR mRNA,
which blocks translation of the GHR protein. Reduction of GHR levels in turn decreases
the circulating level of insulin-like growth factor-1 (IGF-1). IGF-1 is a hormone
that plays an important role in childhood growth and has anabolic effects in adults.
Excess production of IGF-1 results in various disease states including acromegaly.;
Semantic type(s)