Preferred Label : delta9-Tetrahydrocannabinol/Cannabidiol Combination Agent;
NCIt synonyms : d9-THC/CBD Nanoparticle-based Combination Agent;
NCIt definition : A sub-micron spray containing a nanoparticle water soluble equimolar solution composed
of delta-9-tetrahydrocannabinol (delta-9-THC; d9-THC), an analogue of tetrahydrocannabinol
(THC) and the primary form of THC found in the Cannabis sativa L. plant, and cannabidiol
(CBD), a phytocannabinoid derived from Cannabis species, with potential analgesic
activity. Upon administration to the oro-buccal membrane, d9-THC/CBD combination agent
binds to and activates the cannabinoid G-protein coupled receptor (CBR) located in
the central nervous system (CNS). This activates the inwardly rectifying potassium
channels, which decrease presynaptic neuron firing, and inhibits voltage-sensitive
calcium channels that decrease neurotransmitter release. This inhibits excitatory
postsynaptic neuronal transmission, and inhibits the release of pro-inflammatory mediators.
This provides an analgesic effect.;
Drug name : NanaBis;
Molecule name : MDCNB-01;
NCI Metathesaurus CUI : CL1662766;
Origin ID : C180409;
UMLS CUI : C5556347;
Semantic type(s)
- concept_is_in_subset
