Preferred Label : Anti-EGFRvIII/CD3/PD-L1/4-1BB Tetra-specific Antibody GNC-039;
NCIt synonyms : Anti-EGFRvIII/Anti-CD3/Anti-PD-L1/Anti-4-1BB Tetra-specific Antibody GNC-039; EGFRvIII x CD3 x PD-L1 x 4-1BB Tetra-specific Antibody GNC-039;
NCIt definition : A tetra-specific antibody directed against the tumor-associated antigen (TAA) and
epidermal growth factor receptor (EGFR) mutant EGFR variant III (EGFRvIII), the T-cell
surface antigen CD3, the immunosuppressive ligand programmed cell death-1 ligand 1
(PD-L1; cluster of differentiation 274; CD274), and the immune co-stimulatory receptor
4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with
potential immunostimulatory and antineoplastic activities. Upon administration, anti-EGFRvIII/CD3/PD-L1/4-1BB
tetra-specific antibody GNC-039 targets and binds to EGFRvIII, CD3, 4-1BB and PD-L1.
The binding of GNC-039 to EGFRvIII expressed on tumor cells and CD3 expressed on T-cells
may crosslink EGFRvIII-expressing tumor cells and cytotoxic T-lymphocytes (CTLs) and
result in a potent CTL-mediated cell lysis of EGFRvIII-expressing tumor cells. In
addition, the binding of GNC-039 to 4-1BB expressed on a variety of leukocyte subsets
including activated T-lymphocytes results in T-cell co-stimulation and enhanced anti-tumor
activity. At the same time, GNC-039 binds to PD-L1 and prevents PD-L1 from binding
to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed
death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes
and enhances CTL-mediated tumor cell lysis, which may lead to a reduction in tumor
growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival
of CD8-positive T-cells, suppresses the immune system and results in immune evasion.
4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is
an inducible costimulatory receptor that plays a key role in T-cell proliferation,
survival and cytolytic activity. EGFRvIII, a mutant form of EGFR expressed in certain
tumor cell types, plays a key role in tumor cell proliferation and survival.;
Molecule name : GNC-039; GNC 039;
NCI Metathesaurus CUI : CL1662770;
Origin ID : C180405;
UMLS CUI : C5556343;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
