SLFN12-PDE3A Complex Inducer BAY 2666605

Preferred Label : SLFN12-PDE3A Complex Inducer BAY 2666605;

NCIt synonyms : SLFN12/PDE3A Complex Inducer BAY 2666605; Schlafen12 Complex Inducer BAY 2666605;

NCIt related terms : BAY-2666605;

NCIt definition : An orally bioavailable agent that triggers the formation of a complex of the two proteins Schlafen family member 12 (SLFN12) and phosphodiesterase 3A (PDE3A), with potential antineoplastic activity. Upon oral administration, SLFN12-PDE3A complex inducer BAY2666605 triggers the formation of the SLFN12-PDE3A complex. This stabilizes SLFN12 and alters the expression of a set of genes that regulate cell survival, death, and proliferation. This suppresses cell cycle progression and induces apoptosis in cancer cells that specifically express elevated levels of both of these proteins.;

UNII : XC4ZA6OSY6;

CAS number : 2275774-60-0;

Molecule name : BAY 2666605; BAY-2666605;

NCI Metathesaurus CUI : CL1662776;

Details

Origin ID

C180380;

UMLS CUI

C5556331;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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