Preferred Label : SLFN12-PDE3A Complex Inducer BAY 2666605;
NCIt synonyms : SLFN12/PDE3A Complex Inducer BAY 2666605; Schlafen12 Complex Inducer BAY 2666605;
NCIt related terms : BAY-2666605;
NCIt definition : An orally bioavailable agent that triggers the formation of a complex of the two proteins
Schlafen family member 12 (SLFN12) and phosphodiesterase 3A (PDE3A), with potential
antineoplastic activity. Upon oral administration, SLFN12-PDE3A complex inducer BAY2666605
triggers the formation of the SLFN12-PDE3A complex. This stabilizes SLFN12 and alters
the expression of a set of genes that regulate cell survival, death, and proliferation.
This suppresses cell cycle progression and induces apoptosis in cancer cells that
specifically express elevated levels of both of these proteins.;
UNII : XC4ZA6OSY6;
CAS number : 2275774-60-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2275774-60-0
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G-SRS /a ;
Molecule name : BAY 2666605; BAY-2666605;
NCI Metathesaurus CUI : CL1662776;
Origin ID : C180380;
UMLS CUI : C5556331;
Semantic type(s)
- concept_is_in_subset
