Urinary Bladder Tumor Antigen

Preferred Label : Urinary Bladder Tumor Antigen;

NCIt synonyms : BTA; Bladder Tumor-Associated Antigen;

NCIt definition : Bladder tumor associated antigen is a human complement factor H-related protein (hCFHrp), a glycoprotein produced by cancer cells and macrophages but not by normal epithelia. In cell culture, hCFHrp was shown to be produced by several human bladder cancer cell lines, but not by normal epithelial cell lines. By interaction with complement factor C3b, hCFH serves to inhibit the formation of a membrane attack complex, thereby preventing cell lysis. Production of bladder tumor associated antigen may confer a selective growth advantage to cancer cells in vivo by allowing the cells to evade the host immune system. Approved by FDA as a tumor marker for screening test for transitional cell carcinoma.;

Details

Origin ID

C1801;

UMLS CUI

C0676494;

Automatic exact mappings (from CISMeF team)
- bladder tumor-associated antigen [MeSH Supplementary Concept]
- bladder tumor-associated antigen [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- bladder tumor-associated antigen [MeSH Supplementary Concept]
- bladder tumor-associated antigen [MeSH concept]
is_related_to_endogenous_product
- Complement Factor H [NCIt concept]
related_to_genetic_biomarker
- CFH Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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